What are you wanting to use it for? Will it work, yup. But not sure why anyone would want to run it. Would make working on the board components a nightmare.
It is silicone, so in most cases it will float on top. But if you put it on thick, and I would think you would if you are wanting to say, water proof it for dewy mornings, then you are going to want to scrape it away before doing any kind of work. You would also want to remove it around what you are working on so that it doesn't get under an IC and keep it raised up. The fact that they have a remover is very handy!!!